Proteomic evaluation of Copaiba

Article at a glance

You often hear about the groundbreaking research that doTERRA is doing in the field of essential oils. One type of research, proteomics, opens up many new possibilities in the field of essential oil research. Through proteomics, scientists have been able to doEarth Copaiba essential oil and to investigate its influence on the signaling pathways in the body. Although more research is needed, this research provides insight into how the internal and aromatic uses of Copaiba essential oil can affect different body systems.

What is Proteomics and why is it important?

Proteomics takes the study of DNA and the storage and annotation of its data (genomics) one step further by targeting the proteins an organism produces. In proteomic research, researchers are working to identify the function of proteins. This includes how proteins change and interact with everything around them, including essential oils.

Essential oils are biologically active compounds. When introduced into the human organism, they have the potential to affect everything they come into contact with. Through research, we discover that each essential oil has a unique biochemical fingerprint. This is a guide to how they affect signaling pathways and promote protein activity. This activity can affect the structure and function of our body's tissues. doTERRA is collaborating with research partners on proteomic research to determine how essential oils can affect our bodies and to further understand how to use them most effectively. Now that you understand the importance of this research, let's take a look at how it was used by doTERRA scientists to make the essential oil of Copaiba to study.

The study

doTERRA Senior Director of Research & Quality Control, Dr. Cody Beaumont, and research partners used proteomic technologies to investigate the relationship between a protein-coding gene known as Akt3 and the regulation of the pI3K/Akt/mTOR signaling pathway in the presence of CPTG Copaiba essential oil. This cellular pathway influences numerous cellular functions and is essential for healthy cell growth, proliferation and metabolism2. In addition, the researchers modified the expression of Akt3 in different tissues to develop a better understanding of how Copaiba can affect signaling pathways in various body systems. They hoped that the tissue-specific response data could help guide future models for essential oil use by providing information on the optimal route of administration.

The results

What Dr. Beaumont and his colleagues found that, depending on the cell tissue, Copaiba strongly influenced pI3K/Akt/mTOR signaling. For example, where Akt3 is present (i.e., cells in the central nervous system and kidneys), the regulatory effects of Copaiba positive on the signal path. While the regulatory effects of Copaiba had a negative effect in cells where Akt3 was absent (liver). Possibly most interestingly, Akt3 expression did not affect the effects of Copaiba on other signaling pathways in all cell types. This includes pathways such as JAK/STAT and MAPK, which influence cell proliferation and immune response.

In conclusion, Akt3 modulation is likely the mechanism of action for the effects of Copaiba on pI3K/Akt/mTOR signaling. This means that in order to experience specific benefits, the route of essential oil administration matters. The lack of influence of Akt3 expression on the JACK/STAT pathway suggests that we still have a lot to learn regarding Copaiba , how it interacts directly with endocannabinoid receptors (CB2R), and how it affects inflammation and the immune response. While these findings are encouraging, they are experimental and more research will be needed to validate them.

What are the next steps?

doTERRA scientists and their research partners hope to expand these findings in the near future to better understand how Copaiba works. The next steps will further focus on how Copaiba influences the cannabinoid receptor-mediated pathways and how this biochemical influence can be used to support the function of various body systems.