Lemongrass essential oil obtained from Cymbopogon flexuosus is mainly composed of the monoterpenoid citral. In an original study conducted by doTERRA scientists, the effect of Lemongrass characterized on the BioMAP® skin fibroblast system using ELISA biomarker analysis and RNA microarrays to measure protein levels and quantify gene expression.
The BioMAP system allowed doTERRA scientists to explore how healthy cellular activity was supported by the essential oil of Lemongrass. The researchers added certain factors to cultured human skin cells and induced an in vitro cellular response that would be expected to be similar to a cellular inflammatory response in vivo. Subsequently, part of the cells was exposed to essential Lemongrass oil, while other cells were left alone.
Both groups of cells were lysed (disassembled) and their internal contents analyzed by enzyme-linked immunosorbent assays (ELISAs). ELISAs are tests that use antibodies to detect a specific protein and measure its concentration in the sample. The proteins of interest in this study are biomarkers known to be increased (produced in excess) in a cell during inflammatory processes. VCAM-1, IP-10, I-TAC, MIG, collagen-I and III, EGFR, and PAI-1 were some of the 17 biomarkers studied.
Han and his collaborators discovered that the Lemongrass exposed cells had significantly lower levels of 11 of the 17 biomarkers compared to cells not exposed to Lemongrass were exposed. Other experiments showed that gene expression (measured by RNA levels) in these cells was also significantly altered. Pathways related to tissue buildup and inflammation were also affected.
The results of this exciting study suggest that essential Lemongrass oil does indeed help support healthy skin, a healthy immune response and overall cellular wellness.*
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*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.